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The prevalence,onset,and type of seizure disorders,as well as seizure control,were studied in a large cohort of 405 individuals with Down syndrome(age range,6 months to 45 years).The evaluation of a questionnaire completed by the subjects'parents and of the patients'medical records indicated that 33(8.1%)of 405 persons with Down syndrome had seizure disorder.With regard to the onset of seizure,a bimodal distribution was noted:40%of patients began having seizures before the age of 1 year,and another 40%started with seizure activity in the third decade of life.In the younger age group,primarily infantile spasms and tonic-clonic seizures with myoclonus were observed,and the older patients often had partial simplex or partial complex seizures as well as tonic-clonic seizures. |
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